@article {Guo_2018,
	title = {Local growth rules can maintain metabolically efficient spatial structure throughout growth},
	journal = {Proceedings of the National Academy of Sciences},
	volume = {115},
	number = {14},
	year = {2018},
	month = {mar},
	pages = {3593{\textendash}3598},
	publisher = {Proceedings of the National Academy of Sciences},
	type = {Article},
	address = {2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA},
	abstract = {A ubiquitous feature of bacterial communities is the existence of spatial structures. These are often coupled to metabolism, whereby the spatial organization can improve chemical reaction efficiency. However, it is not clear whether or how a desired colony configuration, for example, one that optimizes some overall global objective, could be achieved by individual cells that do not have knowledge of their positions or of the states of all other cells. By using a model which consists of cells producing enzymes that catalyze coupled metabolic reactions, we show that simple, local rules can be sufficient for achieving a global, community-level goal. In particular, even though the optimal configuration varies with colony size, we demonstrate that cells regulating their relative enzyme levels based solely on local metabolite concentrations can maintain the desired overall spatial structure during colony growth. We also show that these rules can be very simple and hence easily implemented by cells. Our framework also predicts scenarios where additional signaling mechanisms may be required.},
	keywords = {local rules, Metabolism, spatial structure},
	issn = {0027-8424},
	doi = {10.1073/pnas.1801853115},
	author = {Guo, Yipei and Tikhonov, Mikhail and Michael P. Brenner}
}
