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176 results
2016
Hidenori Tanaka, Zorana Zeravcic, and Michael P. Brenner. 2016. “Mutation at Expanding Front of Self-Replicating Colloidal Clusters”. Physical Review Letters, 117, 23. doi:10.1103/physrevlett.117.238004
Hidenori Tanaka, Zorana Zeravcic, and Michael P. Brenner. 2016. “Mutation at Expanding Front of Self-Replicating Colloidal Clusters”. Physical Review Letters, 117, 23. doi:10.1103/physrevlett.117.238004
We construct a scheme for self-replicating square clusters of particles in two spatial dimensions, and validate it with computer simulations in a finite-temperature heat bath. We find that the self-replication reactions propagate through the bath in the...
Alpha A. Lee, Michael P. Brenner, and Lucy J. Colwell. 2016. “Predicting Protein–ligand Affinity With a Random Matrix Framework”. Proceedings of the National Academy of Sciences, 113, 48, Pp. 13564–13569. doi:10.1073/pnas.1611138113
Alpha A. Lee, Michael P. Brenner, and Lucy J. Colwell. 2016. “Predicting Protein–ligand Affinity With a Random Matrix Framework”. Proceedings of the National Academy of Sciences, 113, 48, Pp. 13564–13569. doi:10.1073/pnas.1611138113
Rapid determination of whether a candidate compound will bind to a particular target receptor remains a stumbling block in drug discovery. We use an approach inspired by random matrix theory to decompose the known ligand set of a target in terms of...
Sophie Marbach, Karen Alim, Natalie Andrew, Anne Pringle, and Michael P. Brenner. 2016. “Pruning to Increase Taylor Dispersion InPhysarum PolycephalumNetworks”. Physical Review Letters, 117, 17. doi:10.1103/physrevlett.117.178103
Sophie Marbach, Karen Alim, Natalie Andrew, Anne Pringle, and Michael P. Brenner. 2016. “Pruning to Increase Taylor Dispersion InPhysarum PolycephalumNetworks”. Physical Review Letters, 117, 17. doi:10.1103/physrevlett.117.178103
How do the topology and geometry of a tubular network affect the spread of particles within fluid flows? We investigate patterns of effective dispersion in the hierarchical, biological transport network formed by Physarum polycephalum. We demonstrate that...
Joy C. Perkinson, Michael J. Aziz, Michael P. Brenner, and Miranda Holmes-Cerfon. 2016. “Designing Steep, Sharp Patterns on Uniformly Ion-Bombarded Surfaces”. Proceedings of the National Academy of Sciences, 113, 41, Pp. 11425–11430. doi:10.1073/pnas.1609315113
Joy C. Perkinson, Michael J. Aziz, Michael P. Brenner, and Miranda Holmes-Cerfon. 2016. “Designing Steep, Sharp Patterns on Uniformly Ion-Bombarded Surfaces”. Proceedings of the National Academy of Sciences, 113, 41, Pp. 11425–11430. doi:10.1073/pnas.1609315113
We propose and experimentally test a method to fabricate patterns of steep, sharp features on surfaces, by exploiting the nonlinear dynamics of uniformly ion-bombarded surfaces. We show via theory, simulation, and experiment that the steepest parts of the...
Miriam H. Huntley, Arvind Murugan, and Michael P. Brenner. 2016. “Information Capacity of Specific Interactions”. Proceedings of the National Academy of Sciences, 113, 21, Pp. 5841–5846. doi:10.1073/pnas.1520969113
Miriam H. Huntley, Arvind Murugan, and Michael P. Brenner. 2016. “Information Capacity of Specific Interactions”. Proceedings of the National Academy of Sciences, 113, 21, Pp. 5841–5846. doi:10.1073/pnas.1520969113
Specific interactions are a hallmark feature of self-assembly and signal-processing systems in both synthetic and biological settings. Specificity between components may arise from a wide variety of physical and chemical mechanisms in diverse contexts...
David Zwicker, Arvind Murugan, and Michael P. Brenner. 2016. “Receptor Arrays Optimized for Natural Odor Statistics”. Proceedings of the National Academy of Sciences, 113, 20, Pp. 5570–5575. doi:10.1073/pnas.1600357113
David Zwicker, Arvind Murugan, and Michael P. Brenner. 2016. “Receptor Arrays Optimized for Natural Odor Statistics”. Proceedings of the National Academy of Sciences, 113, 20, Pp. 5570–5575. doi:10.1073/pnas.1600357113
Natural odors typically consist of many molecules at different concentrations. It is unclear how the numerous odorant molecules and their possible mixtures are discriminated by relatively few olfactory receptors. Using an information theoretic model, we...
Michael P. Brenner and Sidney R. Nagel. 2016. “Leo Philip Kadanoff”. Physics Today, 69, 4, Pp. 69–70. doi:10.1063/pt.3.3146
Michael P. Brenner and Sidney R. Nagel. 2016. “Leo Philip Kadanoff”. Physics Today, 69, 4, Pp. 69–70. doi:10.1063/pt.3.3146
Xiaoling Wang, Stephan A. Koehler, James N. Wilking, Naveen N. Sinha, Matthew T. Cabeen, Siddarth Srinivasan, Agnese Seminara, Shmuel Rubinstein, Qingping Sun, Michael P. Brenner, and DavidA. Weitz. 2016. “Probing Phenotypic Growth in Expanding Bacillus Subtilis Biofilms”. Applied Microbiology and Biotechnology, 100, 10, Pp. 4607–4615. doi:10.1007/s00253-016-7461-4
Xiaoling Wang, Stephan A. Koehler, James N. Wilking, Naveen N. Sinha, Matthew T. Cabeen, Siddarth Srinivasan, Agnese Seminara, Shmuel Rubinstein, Qingping Sun, Michael P. Brenner, and DavidA. Weitz. 2016. “Probing Phenotypic Growth in Expanding Bacillus Subtilis Biofilms”. Applied Microbiology and Biotechnology, 100, 10, Pp. 4607–4615. doi:10.1007/s00253-016-7461-4
We develop an optical imaging technique for spatially and temporally tracking biofilm growth and the distribution of the main phenotypes of a Bacillus subtilis strain with a triple-fluorescent reporter for motility, matrix production, and sporulation. We...
E. Amstad, M. Chemama, M. Eggersdorfer, L. R. Arriaga, M.P. Brenner, and D. A. Weitz. 2016. “Robust Scalable High Throughput Production of Monodisperse Drops”. Lab on a Chip, 16, 21, Pp. 4163–4172. doi:10.1039/c6lc01075j
E. Amstad, M. Chemama, M. Eggersdorfer, L. R. Arriaga, M.P. Brenner, and D. A. Weitz. 2016. “Robust Scalable High Throughput Production of Monodisperse Drops”. Lab on a Chip, 16, 21, Pp. 4163–4172. doi:10.1039/c6lc01075j
Monodisperse drops with diameters between 20 mu m and 200 mu m can be used to produce particles or capsules for many applications such as for cosmetics, food, and biotechnology. Drops composed of low viscosity fluids can be conveniently made using...
2015
Karl R. Stapelfeldt, Frank G. Dekens, Michael P. Brenner, Keith R. Warfield, Ruslan Belikov, Paul B. Brugarolas, Geoffrey Bryden, Kerri L. Cahoy, Supriya Chakrabarti, Serge Dubovitsky, Robert T. Effinger, Brian Hirsch, Andrew Kissil, John E. Krist, Jared J. Lang, Mark S. Marley, Michael W. McElwain, Victoria S. Meadows, Joel Nissen, Jeffrey M. Oseas, Chris Pong, Eugene Serabyn, Eric Sunada, John T. Trauger, Stephen C. Unwin, and Stuart Shaklan. 2015. “Exo-C: A Probe-Scale Space Observatory for Direct Imaging and Spectroscopy of Extrasolar Planetary Systems”. In Techniques and Instrumentation for Detection of Exoplanets VII. Vol. 9605. 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA: SPIE. doi:10.1117/12.2191720
Karl R. Stapelfeldt, Frank G. Dekens, Michael P. Brenner, Keith R. Warfield, Ruslan Belikov, Paul B. Brugarolas, Geoffrey Bryden, Kerri L. Cahoy, Supriya Chakrabarti, Serge Dubovitsky, Robert T. Effinger, Brian Hirsch, Andrew Kissil, John E. Krist, Jared J. Lang, Mark S. Marley, Michael W. McElwain, Victoria S. Meadows, Joel Nissen, Jeffrey M. Oseas, Chris Pong, Eugene Serabyn, Eric Sunada, John T. Trauger, Stephen C. Unwin, and Stuart Shaklan. 2015. “Exo-C: A Probe-Scale Space Observatory for Direct Imaging and Spectroscopy of Extrasolar Planetary Systems”. In Techniques and Instrumentation for Detection of Exoplanets VII. Vol. 9605. 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA: SPIE. doi:10.1117/12.2191720
``Exo-C'' is NASAs first community study of a modest aperture space telescope mission that is optimized for high contrast observations of exoplanetary systems. The mission will be capable of taking optical spectra of nearby exoplanets in reflected light...
E. Amstad, M. Gopinadhan, C. Holtze, C. O. Osuji, M.P. Brenner, F. Spaepen, and D. A. Weitz. 2015. “Production of Amorphous Nanoparticles by Supersonic Spray-Drying With a Microfluidic Nebulator”. Science, 349, 6251, Pp. 956–960. doi:10.1126/science.aac9582
E. Amstad, M. Gopinadhan, C. Holtze, C. O. Osuji, M.P. Brenner, F. Spaepen, and D. A. Weitz. 2015. “Production of Amorphous Nanoparticles by Supersonic Spray-Drying With a Microfluidic Nebulator”. Science, 349, 6251, Pp. 956–960. doi:10.1126/science.aac9582
Amorphous nanoparticles (a-NPs) have physicochemical properties distinctly different from those of the corresponding bulk crystals; for example, their solubility is much higher. However, many materials have a high propensity to crystallize and are...
Rebecca W. Perry, Miranda C. Holmes-Cerfon, Michael P. Brenner, and Vinothan N. Manoharan. 2015. “Two-Dimensional Clusters of Colloidal Spheres: Ground States, Excited States, and Structural Rearrangements”. Physical Review Letters, 114, 22. doi:10.1103/physrevlett.114.228301
Rebecca W. Perry, Miranda C. Holmes-Cerfon, Michael P. Brenner, and Vinothan N. Manoharan. 2015. “Two-Dimensional Clusters of Colloidal Spheres: Ground States, Excited States, and Structural Rearrangements”. Physical Review Letters, 114, 22. doi:10.1103/physrevlett.114.228301
We study experimentally what is arguably the simplest yet nontrivial colloidal system: two-dimensional clusters of six spherical particles bound by depletion interactions. These clusters have multiple, degenerate ground states whose equilibrium...